The antibacterial drug is effective against common pathogens of angina and other infectious diseases. Structural analogues of Amoxiclav, like this antibiotic, belong to the generation of protected penicillins. Clavulanic acid prevents the breakdown of the drug under the action of bacterial enzymes, which increases the effectiveness of therapy.
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The composition of the antibiotic (active substances)
Pathogenic organisms constantly mutate, adapt to the drugs used. Many strains no longer respond to penicillins in their pure form. More effective generations of antibiotics have been created, as well as components, the addition of which to the active substance prevents its degradation.
Amoxiclav in accordance with WHO recommendations is considered the "gold standard" for the treatment of many infectious diseases. The drug contains a combination of a semisynthetic antibiotic of the penicillin group with clavulanic acid (clavulanate).
Amoxicillin in the composition of the drug has a wide spectrum of antimicrobial activity, but it breaks down in the intestine under the influence of beta-lactamase bacteria. Other beta-lactam antibiotics (penicillin, cephalosporin) are also subject to degradation.
The bactericidal effect of Amoxiclav is provided by amoxicillin, but without clavulanate, the antibiotic could not resist the enzymes of bacteria.
Properties of clavulanic acid - the second active substance:
- prevents the destruction of amoxicillin;
- irreversibly inhibits bacterial beta-lactamases;
- possesses its own antibacterial activity against staphylococcal and streptococcal infections, moraxella, gonococcus, chlamydia, legionella;
- to a lesser extent affects enterococcus and Pseudomonas aeruginosa.
Amoxiclav is produced in Slovenia. The price of the drug varies from 110 to 890 rubles. The cost depends on the concentration of substances and the form of release of the drug. A suspension for oral administration and a powder for the preparation of an injectable solution are more expensive than tablets.
Cheap analogues of Amoxiclav domestic producer
Completely similar drugs may differ in excipients, price, manufacturer. There are few cheap Russian analogues with the same composition as Amoksiklav.
The cost of the drug Amoxicillin + Clavulanic acid-Vial in the form of a powder for dissolution and iv administration is from 60 to 90 rubles. Relatively affordable domestic products Ecoklav and Arlet. Arlet tablets contain amoxicillin / clavulanic acid in a ratio of 825/125 (the highest concentration of antibiotic for adults). The price of packaging (14 pcs.) Is more than 400 rubles.
The cost of Ecoclave in tablets (15 pcs.) With the content of active ingredients 250/125, 500/125, 875/125 - 215, 300 and 375 rubles, respectively. Release in powder form for suspension. This form is considered the most suitable for children. The price of Ecoclave in the form of a powder with a ratio of components 125/31 is 159 rubles, 250/62 - 264 rubles.
Relatively cheap analogues of Amoxiclav are produced by pharmaceutical companies in Belarus. The names of the preparations are Amclav, Amoklav-625 and 1000. The cost varies from 90 to 360 Russian rubles.
In the list of Amoxiclav analogues by the form of release and composition - preparations of Western companies:
- Augmentin - from 150 to 470 rubles (suspension).
- Flemoklav Solutab - 330 rubles.
- Amoksiklav Kviktab - 390 rubles.
- Panklav - 370 rubles.
Amoxiclav Quiktab and Augmentin are antibiotics prescribed during pregnancy.
Preparations 2–4 are available in tablet form. Means 2 and 3 are dispersible tablets. Before taking such drugs, they are dissolved in 30–80 ml of water or absorbed in the mouth. You can not take similar drugs at the same time, as this leads to an overdose.
If the doctor prescribed Amoxiclav to the patient and this medicine is not in the pharmacy, then the drug can be replaced with the full analogue - Augmentin. Be sure to observe the dosages indicated by the doctor so that the content of amoxicillin meets the recommendation of a specialist.
Incomplete structural analogues of the drug
Cheap analogues can be found among drugs that contain only amoxicillin. Amoxiclav cannot be replaced with such a medicine on its own, since the activity of an unprotected beta-lactam antibiotic may be insufficient to destroy the causative agents of the disease. Such initiative will only lead to the fact that it will increase the resistance of bacteria.
The cost of Russian drugs in tablets: Amoxicillin and Amosin (250 and 500 mg of antibiotic) - from 35 to 76 rubles. Amosin is also produced in the form of a powder, from which a suspension is prepared. This is also a cheap drug (56 rubles).
Foreign incomplete structural analogues: Ospamox (from 56 to 100 rubles), Amoxicillin Hemofarm (64–100 rubles), Amoxicillin Sandoz (175 rubles), Flemoxin Solutab (240–500 rubles).
Drugs similar in pharmacological properties
In addition to the full structural analogues of the original drug (generics), incomplete analogues in composition, doctors can prescribe drugs with the same therapeutic effect. The latter are also called group analogues. For amoxicillin, such a drug is a related antibiotic with an extended spectrum of action - ampicillin. His "age" is about 60 years.
Ampicillin is destroyed in the digestive tract by an enzyme of certain types of bacteria. Resistance to this medicine is noted at staphylococci. The number of bacterial strains resistant to beta-lactam antibacterial agents increases annually.For this reason, historically, the first antibiotics are prescribed less and less.
Doctors rely more on new, protected penicillins, cephalosporins, macrolides, and azalides. In this case, amoxicillin + clavulanic acid is considered the antibiotic of choice. For allergies to penicillins or for other reasons, cephalosporins are prescribed (Cefixim, Suprax, Pancef, Zinnat).
The choice of a specialist depends on the nature of the disease, the age of the patient and previously prescribed drugs.
The doctor, following WHO instructions, can prescribe macrolides and azalides. Antibiotics of this group act bacteriostatically, do not kill bacteria, but stop the development, but rarely cause allergies. The most commonly used drugs of the group are Sumamed, Hemomycin and Ekomed (the active substance is the same - azithromycin). Unfortunately, bacteria acquire resistance to macrolides relatively quickly.
The list of similar drugs for children
Amoxiclav and structural analogs may contain different amounts of amoxicillin / clavulanic acid: 125/31, 250/125 or 62, 400/57. It is very convenient, especially for treating children. The calculation of tablets or suspensions should be carried out precisely on amoxicillin, not taking into account the amount of clavulanate.
What complete and incomplete structural analogues of Amoxiclav can children take:
- Vial Amoxicillin + Clavulanic acid;
- Flemoxin and Flemoklav Solutab;
- Amoxiclav Quicktab;
- Augmentin;
- Ecoclave.
Taking Amoxiclav or a structural analogue of 250/125 mg can be replaced with two doses of 125/31, regardless of the different content of clavulanic acid. A safe daily dose of this component is 600 mg.
Amoxiclav analogues according to the mechanism of action Suprax and Sumamed in the form of a suspension are prescribed from 6 months. The advantage of drugs containing azithromycin is taking only one dose per day in a short course (3-5 days). This drug is called a “3 day antibiotic” in everyday life.
The pediatrician will definitely clarify that it is better for the child to give the medicine in the form of a suspension or syrup. In the first case, you need to add water to the powder bottle and shake. Suspension can not be stored for a long time, like syrup, drops and tablets.
Amoxiclav contains two components - amoxicillin and clavulanic acid. They are well absorbed in the digestive tract. This protected penicillin antibiotic is effective against a large number of bacterial strains. Unlike “ordinary” amoxicillin, it is not destroyed by bacterial enzymes in the human body.
