De-nol is an antimicrobial action pill for stomach ulcers that prevents stomach inflammation and the occurrence of peptic ulcers. How to take De-nol, from what it helps and to whom it is contraindicated?
Material Content:
Composition and form of release
About 75% of people suffer from stomach problems, in particular peptic ulcers, and they do not always arise from malnutrition. Inflammation of the stomach occurs due to the action of bacteria and the timely intake of an antimicrobial drug can prevent ulcers on the walls of the gastrointestinal tract. De-nol is an antimicrobial agent that has an astringent effect and is able to fight the bacterium Helicobacter pylori, which most often causes gastrointestinal ulceration.
The drug is sold under the trade name De-nol and in its composition it has bismuth tripotassium dicitrate (304.6 mg or 120 mg). In addition, the medicine consists of starch, glucose and magnesium stearate.
De-nol tablets are round, with convex cream sides, which are engraved with "gbr 152" and a square pattern. At the same time, they are odorless and are packed in standard blisters of 8 tablets each. In each box of medicine there is an instruction, but it is highly recommended that you consult with your doctor before using it.
Pharmacological action and pharmacokinetics
How do ulcers and wounds form in the stomach? Helicobacter (a type of bacterium) enters the intestines and begins to actively multiply there, as well as toxins.These toxins tend to completely dissolve the film that is located on the walls of the stomach and protects them. Without this film, gastrointestinal mucosa become vulnerable to gastric juice, as well as food enzymes and become covered with ulcers.
De-nol has antibacterial and protective effects, protecting the gastrointestinal tract from the pathogenic effects of bacteria and the formation of ulcerative wounds.
In addition to its bactericidal activity, the drug stops the spread of the inflammatory process inside the digestive tract and, with the help of an astringent effect, promotes coagulation of proteins. Thanks to its activity, the gastrointestinal mucous membranes are restored and can again protect the organ.
The effectiveness of the medication is due to the insolubility of bismuth oxychloride and citrate, which create special compounds with a protein substrate. These compounds are a film that settles on the gastric walls in those places where their erosion begins and ulcers have already appeared, thereby stopping their spread.
In addition, De-nol also has the ability to:
- form a bicarbonate secretion;
- stimulate the protective mechanisms of the gastrointestinal tract;
- strengthen the mucous membranes.
Taking the medication promotes faster regeneration of mucosal cells and the growth of protective films of the stomach. In this case, bismuth subcitrate is not prone to absorption - it is practically not absorbed into the blood, acting strictly in the gastrointestinal tract. That small amount of the drug, which nevertheless enters the bloodstream, is excreted through the urinary system during the day, and the bulk of the drug through the colon with fecal masses.
What is de-nol prescribed for?
The drug is dispensed in pharmacies without a prescription, but before using it, you should still consult your doctor to avoid possible problems. Indications for taking the medication are ulcerative lesions of the stomach and duodenum (acute and chronic forms), as well as gastritis, dyspepsia and irritable bowel syndrome with severe diarrhea. De-nol is also used as a prophylactic if the patient has a history of gastrointestinal ulcer.
How to take the drug
The dosage regimen is prescribed by the attending physician (gastroenterologist). This information contains instructions for use - it comes in every package of De-nol.
You can use the medication for children over 4 years old:
- Patients from the age of twelve: 4 times a day, 1 tablet each (you can drink 2 tablets and reduce the intake to 2 times).
- For children aged 8 to 12 years, 2 tablets per day with an interval of 6 hours, and for children under 8 years of age, the dose is prescribed at the rate of 4 mg per 1 kg of body weight.
Take De-nol for gastritis and other diseases should be taken orally, half an hour before or after a meal, washed down with water for 4-8 weeks. The course of treatment can be changed by decision of the doctor.
Pregnancy and lactation
De-nol is not approved for use by women in a position or breast-fed. The ban is imposed in view of the possible negative impact on the child. It is possible to use De-nol of a pregnant or lactating mother only when the potential benefit for her is significantly higher than the harm to her child. If a woman was prescribed De-nol during the period of feeding, then it should be discontinued during the course of treatment and replaced with milk mixtures.
Drug interaction
In view of the peculiarities of the action of the drug, it can not be mixed with other medicines, so as not to level its effectiveness. A number of food products should be limited: milk and fruit drinks, fruits and vegetables, since they significantly reduce its effectiveness. De-nol is prescribed with other drugs that have anti-Helicobacter pylori activity - this is necessary to reduce the course of treatment and quickly recover the patient.
Reception of De-nol with other drugs has its own characteristics:
- the drug reduces the absorption of tetracycline and, accordingly, its effectiveness;
- may cause an overdose if the patient consumes a number of drugs with bismuth together with Denol;
- any antacid drugs reduce the effectiveness of De-nol.
Excessive concentration of bismuth in the body can not only cause problems with the gastrointestinal tract, but also adversely affect the central nervous system, therefore it is necessary to limit preparations with a similar composition for 2 months.
Contraindications, side effects and overdose
De-nol has its contraindications.
Among them:
- kidney problems
- hypersensitivity to the components of the drug.
If the reception conditions are not observed, the patient may have side effects:
- nausea;
- constipation;
- allergies (itching, urticaria).
If the patient does not follow the doctor’s recommendations and the recommended dosage, bismuth will accumulate in the body and an overdose of the drug will occur. It is accompanied by one symptom - impaired renal function, which can lead to systemic malfunctions in the body. With immediate treatment (gastric lavage, intake of absorbents, hemodialysis), the disorders are completely reversible.
Drug Analogs
All existing analogues of De-nol incorporate the same active substance and are used as part of antiulcer therapy.
Among them, the most effective are:
- Bismuth subcitrate.
- Gastro Norms.
- Vis-nol.
These drugs have a pronounced antibacterial and antiviral effect and stop the spread of inflammation in the stomach and intestines.
De-nol is a high-quality and effective medication that is recommended by gastroenterologists as part of complex therapy for the treatment of ulcerative lesions of the gastrointestinal wall. He does not have numerous contraindications for use and quickly enough restores the affected areas of the gastrointestinal mucous membranes.
