Nimesil: instructions for use, composition, indications and contraindications, analogues of NSAIDs

When the attacks of pain become very strong and the person simply can’t stand it anymore, a drug is required that can act quickly and effectively. Nimesil meets these requirements, it is used in emergency cases and successfully fights pain. In order to avoid harming your health instead of benefit, you need to study in detail the instructions for use of Nimesil. After all, such a strong medicine has a number of contraindications, which must be taken into account.

Release form, composition and packaging

The drug is presented in a convenient form - a light yellow granular powder with a pronounced orange smell. An oral suspension is prepared from it.

The main component of the drug is nimesulide, which is present in a dosage of 100 mg in a standard two-gram packet with granules.

For ease of use and extension of shelf life, the medication includes:

• citric acid;
• sucrose;
• macrogol cetyl ether 1000;
• maltodextrin;
• orange flavor.

Powder of 2 grams is placed in a three-layer sachet of polyethylene, foil and cellulose. Carton packaging contains 30, 15 or 9 doses of Nimesil.In addition to the medicine, in the box there is an insert with instructions for use.

Pharmacological action and pharmacokinetics

The active substance of the drug belongs to a number of sulfonamide non-steroidal anti-inflammatory drugs (NSAIDs).

It has a direct effect on the cyclooxygenase enzyme, blocking the production of prostaglandins. The latter work as suppliers of painful impulses to the brain, and also contribute to the spread of inflammation in the body. Thus, reducing the number of prostaglandins, nimesulide has a positive effect, stopping the pain.

Among the characteristics of the drug:

• pain relief of various origins;
• early elimination of inflammation;
• swelling reduction;
• lower fever.

Due to its convenient form, the medicine is rapidly absorbed from the stomach into the blood and reaches its maximum concentration in the body within 2 to 3 hours after administration, which ensures its high efficiency.

The analgesic effect lasts for 5 to 6 hours, after which half the dose of nimesulide is excreted by the kidneys.

Indications Nimesil

The main emphasis made in the instructions and stipulated by doctors and pharmacists is that the drug is intended for symptomatic therapy during acute pain attacks.

The reason for such sensations can be diseases of different genesis:

• urological;
• gynecological;
• Dental
• traumatic;
• cardiological;
• otorhinolaryngological.

In addition, there are a number of indications in which the use of the drug is possible.

Among them:

• acute pain in the back, lower back, other localization in the musculoskeletal system;
• different types of injuries (bruises, sprains, dislocations);
• tendon inflammation;
• joint pain
• rheumatism, sciatica;
• migraines, headaches;
• arthritis of various shapes;
• menstrual disorders, accompanied by pain;
• toothache with pulpitis, periodontitis, after treatment or tooth extraction;
• postoperative period (regardless of the etiology of the disease).

The decision on the use of the drug and the necessary dosage is prescribed by the doctor. It is based on the symptoms and nature of the disease, and also takes into account the individual characteristics of the patient.

Age restrictions on admission

Since the drug, due to its speed and effectiveness, has an increased toxic effect on the liver and other organs, it is necessary to strictly observe the rules for the use of nimesulide.

This is especially true for the recommended age of patients who can take medicine to stop pain or reduce inflammatory processes.

• Children under 12 years of age are prohibited from prescribing Nimesil. You must choose another drug from the group of analgesics.
• Older people also need to be careful with this remedy. Doctors recommend that you try first the minimum dose of the drug, and then, if the body tolerates it normally, you can increase the dosage to the optimum.

Nimesil powder: instructions for use

In order to effectively use the drug in question, it is necessary to take into account all the instructions of the doctor on its use and follow the instructions that are enclosed in the package with the medicine.

How to breed Nimesil powder

Preparing a drug suitable for consumption is very simple.

To do this, you must:

1. Take one dose of the drug - 2 gram sachet.
2. Open it and pour the granules into a glass.
3. Pour the powder with 100 milliliters of clean water, heated to 30 - 36 degrees.
4. Stir contents thoroughly.

It is necessary to take the suspension immediately after preparation, to store the medicine in this form is impractical.

Dosage regimen

Since it is forbidden to use the drug in childhood, the recommended dosage for effective action is the same for all age categories (from 12 years old).

The maximum daily dose for adults is 200 mg of nimesulide, it is divided into two doses. So, you need to take 1 sachet of funds twice a day.

For patients older than 65 years, a doctor adjusts the dosage. Elderly patients are initially prescribed the minimum dose, then, under the supervision of a doctor, they are increased to the nominal.

Special instructions for use

Drink Nimesil after meals. If you take the drug on an empty stomach, there is a high probability of irritation of the mucous membrane, which threatens with severe pathologies of the digestive tract - erosion, ulcer, gastritis.

For the same reason, you must adhere to the lowest dose, which effectively eliminates the symptoms of pain or inflammation. In addition, taking the drug for more than two weeks is not possible.

The drug begins to act within half an hour after taking, and the effect lasts, on average, about 5-6 hours. If no improvement has occurred, you should consult a doctor to change the medicine to another anti-inflammatory drug.

Pregnancy and lactation

The use of such a potent drug by women in a special situation is not recommended by doctors.

Some doctors talk about the possibility of using Nimesil in the first and second trimester, but only with caution, and if the risk to the health of the mother exceeds the possible consequences after taking the medicine. The selection of a painkiller occurs individually in each case.

Regarding the third trimester of pregnancy, all doctors are unanimous: the drug is strictly prohibited.

Possible negative consequences from the use during this period:

• jumps in blood pressure;
• risk of early closure of the ductus arteriosus;
• pathology of fetal development;
• renal failure (in mother and unborn child);
• water shortage;
• decrease in uterine contractions;
• internal bleeding;
• swelling.

Due to its high toxicity and ability to pass into breast milk, the drug should not be treated by nursing mothers.

Doctors do not recommend using the tool for those women who plan to become pregnant, since the active substance reduces the ability to conceive.

Drug Interactions with Other Drugs

Before taking "Nimesil", you should learn about the compatibility of the drug with other medicines. After all, otherwise the manifestation of unpleasant symptoms is possible.

1. Glucosteroids and blood clots, while using NSAIDs, increase the likelihood of bleeding and ulcerative lesions of the gastrointestinal tract.
2. The concomitant use of cyclosporine enhances the toxic effects on the liver and kidneys.
3. The drug reduces the effectiveness of diuretics and antiarrhythmic drugs, as well as drugs for hypertension.
4. ACE inhibitors in combination with nimesulide can cause renal failure.
5. The use of furasemide along with the drug slows down the withdrawal of sodium and potassium.
6. Drugs containing lithium exacerbate their side effects if taken together with NSAIDs.

It is important to monitor the dosage of the drug and not to take it together with other non-steroidal anti-inflammatory drugs.

Special instructions for the use of NSAIDs

There is some disagreement about the need to use Nimesil during fever and fever. This issue is associated with the insecurity of the drug, more precisely with the large number of side effects that it causes.

Some manufacturers of the drug indicate the state of heat as a contraindication to the use of the drug, and in the instructions of others, an increased temperature (more than 38.5 degrees) is an indication for taking nimesulide.

Be that as it may, you should always follow the doctor's recommendations, because the treatment depends on the specific individual case, symptoms and condition of the patient at a certain point.But such disputes oblige you to well weigh all possible risks and expected benefits before taking the drug in order to choose the best option.

Like most non-steroidal anti-inflammatory drugs, this drug has an effect on concentration and has a pronounced sedative effect.

Therefore, after taking Nimesil, you should refuse to drive a car, and if this is impossible, then be as careful as possible when driving. Such a warning also applies to the management of other mechanisms: you must be especially careful not to harm your health.

Drug compatibility with alcohol

In the instructions for the drug, there are no specific instructions as to whether alcohol can be consumed with the Nimesil preparation.

But doctors in this matter are absolutely categorical: while taking these substances, they have a detrimental effect on the body. The fact is that both ethyl alcohol and the active component of the drug under discussion have toxic properties, destroying the cells of internal organs. First of all, the liver suffers, which increases the risk of developing its insufficiency and even hepatitis.

In addition, the effectiveness of Nimesil in terms of pain relief is significantly reduced due to the action of alcoholic beverages. That is, there is no use for such treatment, only an increase in toxic load. A particularly dangerous consequence of this combination may be a person’s inability to adequately assess his condition under the influence of alcohol, and in the event of development of side effects such as internal bleeding, he simply will not notice them. In such a situation, there is a high probability of death.

Chronic alcoholism is a contraindication to the use of the drug. Indeed, in such a person all organs already have certain pathologies, and nimesulide will only aggravate their condition.

Is it possible to take a drug to relieve headaches that occur after a hangover? The answer to this question depends on how much time has passed after drinking strong drinks. The required length should be at least 6 hours - this is exactly what is needed to remove most of the alcohol from the blood. But it’s better, nevertheless, that about 12 hours after the last drink of alcohol have passed.

And what about the reverse interaction? If you take "Nimesil" to eliminate pain, then you can treat yourself to strong drinks only after 12 hours. It takes so much time to remove the drug from the body.

Contraindications, side effects and overdose

The drug under discussion is recommended for use in second-line therapy, that is, if simpler medicines did not give the desired result.

The effectiveness of nimesulide has a flip side: it has an increased toxic effect on organs. That is why the drug has a long list of contraindications and side effects.

You can not use the drug in such conditions:

• individual intolerance to the components of the drug;
• allergy to aspirin, other NSAIDs;
• children under 12 years old;
• severe pathologies in the functionality of the kidneys;
• internal bleeding in the digestive tract;
• heart failure;
• active liver disease;
• clotting problems;
• 3 trimester of pregnancy;
• exacerbation of a stomach ulcer or duodenal ulcer;
• aspirin asthma;
• time after coronary artery bypass grafting;
• type 2 diabetes;
• period of breastfeeding;
• arterial hypertension;
• fever in acute respiratory infections;
• elevated levels of potassium in the blood;
• alcohol or drug addiction.

Among the possible adverse reactions, the instructions indicate:

• vomiting, acute epigastric pain;
• stool disorders, constipation;
• heart rate failures, pressure jumps;
• anemia;
• fatigue;
• hyperkalemia
• swelling and hemorrhage in the skin;
• dizziness;
• hypertension
• dermatitis, rash, redness;
• muscle cramps;
• excessive sweating;
• labored breathing;
• bronchospasm;
• flatulence;
• ulcer, gastritis, bleeding in the stomach;
• hematuria;
• inflammation of the liver;
• problems with urination;
• bleeding gums;
• blurry vision;
• feeling of panic, fear;
• troubled sleep;
• renal failure;
• decrease in body temperature;
• irritability, aggressiveness.

If you increase the recommended dose or take the drug without observing the required interval, overdose symptoms occur:

• nausea;
• vomiting
• stomach ache;
• bleeding in the digestive tract;
• general weakness;
• drowsiness;
• state of apathy;
• increase in blood pressure.

Very rarely, with severe dose excess, cases of acute renal failure and coma have occurred.

Cheap analogues of Nimesil

Among the synonyms of the drug in domestic pharmacies there are many medicines with the same active substance. These are granules for the preparation of a medicine, tablet, gel or suspension. They differ in the ratio of the active drug, additional components, duration and effectiveness, as well as side effects.

The composition of these drugs also includes nimesulide:

• Nemulex
• Nise
• "Flolid";
• "Actasulide";
• "Prolide";
• Aponil;
• Nimesan
• Nimulide.

Also similar in their action can be called other anti-inflammatory and pain medication.

Among them:

• "Meloxicam";
• Chondroxide;
• Diclofenac
• "Artromax";
• Glucosate
• Ibuprofen
• "Aspirin".

It is not recommended to replace the prescribed drug with analogues on your own, because each drug has its own indications, contraindications and features of interaction with other medicines.