A popular remedy belongs to the group of proton pump inhibitors, it is considered an effective cure for heartburn and stomach pain. The effect of Omez analogues is also to reduce the acidity of the stomach. Drugs normalize pH, prevent the development of gastritis, the appearance of ulcers.
Material Content:
Release forms and composition
Omez is produced in capsules having an enteric coating. The coating is resistant to acid in the stomach, which protects the medicine from destruction. A shell with such properties is called enteric. The contents of the capsules is a granular powder of white or light beige color.
Another dosage form - lyophilisate - is used to prepare the solution. The fluid is used for infusion. Lyophilization of the active substance provides better mixing with water and complete dissolution.
Another lyophilisate is released under the trade name Omez Insta. The powder is packaged in disposable bags. The product is diluted with water, the resulting suspension is taken orally.
Omeprazole is contained in capsules in dosages of 10, 20 or 40 mg. The mass of the substance in one sachet is 20 mg. Omez is produced in India. The cost of drugs in Russian pharmacies: packaging of capsules 10 pcs. - 70 rubles., A bottle with powder for the preparation of the lyophilisate - 165 rubles., Omez Insta (10 sachets) - 85 rubles.
Why is Omez prescribed
Small glands in the inner lining of the stomach produce hydrochloric acid to lower the pH to 1.5.In a strongly acidic environment, the activity of the enzyme of the stomach increases, microorganisms die. After food intake, during starvation, overeating, a different amount of acid is produced. The debugged mechanism is disturbed in case of gastrointestinal diseases and stress.
Changes in secretion serve as a trigger for inflammation of the gastric mucosa and the next section of the digestive tract - the duodenum. There are conditions for the development of peptic ulcer (peptic ulcer). The allocation of excess acid and the inflammatory process are accompanied by heaviness in the abdomen, nausea, pressure and pain in the epigastric region, heartburn, belching.
Omez reduces the number of hydrogen protons that determine the acid properties of the gastric contents, its pH.
The use of the drug is most effective in the following diseases in adults:
- peptic ulcer caused by the use of non-steroidal anti-inflammatory drugs;
- Helicobacter pylori infection (in combination with antibiotics);
- gastroesophageal reflux disease (GERD);
- inflammation of the esophagus with reflux esophagitis;
- Zollinger-Ellison syndrome;
- relapses of peptic ulcers;
- hyperacid gastritis.
It is possible to treat children over 1 year old with weight over 10 kg with Omez. The drug is used in pediatrics for symptomatic therapy of heartburn and reflux of gastric juice in the esophagus with GERD. Children over 4 years old receive Omez with Helicobacter pylori infection in conjunction with antibiotics.
Analogs and substitutes of the drug in tablets and capsules
Omeprazole blocks the secretion of acid by special cells in the gastric mucosa. Such agents are called proton pump or pump inhibitors (PPIs). These are the most effective drugs to reduce acidity in GERD, peptic ulcer and similar conditions.
Omeprazole is part of the complete Omez analogue in tablets - the drug Losek Maps. The content of the active substance: 10 or 20 mg. The cost of packaging (28 tablets) is 620 rubles.
Intestinal Soluble Omeprazole Capsules are available in Russia and Belarus. The cost of packaging (10 pcs.) Is 18-30 rubles. Enteric capsules Ultop, Omitox, Gastrozole, Orthanol are produced in India, Russia, Slovenia.
Analogs and substitutes for the drug Omez differ in the mechanism of action. PPIs are absorbed in the small intestine, penetrate the gastric mucosa with blood, and block the proton pump (H + -K + -ATPase enzyme). Regardless of the reason that does not enhance the secretion of acid, it decreases due to the lack of hydrogen ions.
The action of structural analogues of Omez occurs within an hour. The secretory activity of cells is fully restored after 3-5 days.
Incomplete analogues - Omez DSR and Omez D - contain domperidone and omeprazole in various ratios. Active substances complement each other's effect. Omeprazole reduces acidity, domperidone is a prokinetics that accelerate the passage of food from the stomach to the intestines.
Group analogues - other IPPs. Lansoprazole is part of Epicurus capsules. The price of packaging (14 capsules) is 400 rubles. Pantoprazole is the active substance of the drugs Canon, Panum, Krosacid, Nolpaza. The last drug is released in the form of tablets. The cost of packaging (28 pcs.) - 270 rubles.
Relatively new PPIs contain rabeprazole. The medicine begins to act one hour after ingestion, has an anti-helicobacter effect. The cost of drugs Rabelok, Beret, Zulbeks, Noflux, Razo - from 300 to 500 rubles.
Omez substitutes - H2 receptor blockers:
- Ranitidine;
- Quamatel;
- Ranisan;
- Histac
- Zantac.
Drugs in this group bind histamine, which enhances the production of acid in the stomach. Ranitidine belongs to the second generation, Famotidine is a more active drug from the third generation of drugs of this group. Nizatidine and roxatidine are the fourth and fifth generations.
H2 blockers eliminate heartburn, acid belching, bloating and abdominal pain caused by reflux, high acidity.They are 5–10 times cheaper compared to PPIs, but they act only on part of the process of acid formation in the stomach. Means reduce the secretion, depending on histamine, food, hormones.
Doctors suggest taking PPIs during gastritis during the day, H2 blockers at night.
Other substitutes for Omez - antacids in tablets:
- Rutacid;
- Gastracid
- Becarbon;
- Gaviscon;
- Gastal.
Antacids quickly reduce acidity, save from heartburn due to the binding of protons directly in the lumen of the stomach. The mechanism of acid production is not affected. Antacids are used to eliminate symptoms, PPIs and H2 blockers - to influence the cause of the disease.
Instructions for use of the drug
Omez with heartburn and acid belching is taken in a single dose of 20 mg before breakfast or dinner for two weeks. Do not chew a tablet or capsule, but swallow it whole. Content must be released in the intestines.
The usual dose for reflux, heartburn is 20 or 40 mg of omeprazole per day. The course is from 4 to 8 weeks. Further, you can reduce the dosage to 10 mg / day. To prevent relapse, it is enough to drink one capsule of omez per day for six months.
In case of impaired liver function, take no more than 20 mg of omeprazole per day.
During the treatment of peptic ulcers, 20 mg / day are prescribed. The duration of the course is from 2 to 8 weeks, depending on the indications. With an exacerbation of peptic ulcer, 1-2 capsules / day (20-40 mg) are prescribed. The dose for Helicobacter pylori infection is 1 capsule twice a day in combination with antibiotics. Dosages for Zollinger-Ellison syndrome are selected depending on the acidity of the gastric contents (60–80 mg / day).
Omez during pregnancy and lactation
Before prescribing a PPI for a pregnant woman, the doctor compares the benefits of using it for maternal health and the risks to the fetus. If the first outweighs, then the medicine is prescribed in the minimum dosage.
If necessary, treatment with omez during lactation ceases breastfeeding. Or choose an alternative from among completely safe drugs.
Drug interaction
The metabolism of omeprazole in the liver can slow down the breakdown of diazepam and other benzodiazepines (tranquilizers), sleeping pills, and warfarin. Omez increases the plasma level of a large group of drugs. Dose reduction is required while taking with imipramine, clomipramine, ketoconazole, itraconazole, digoxin, clarithromycin, cyclosporine.
Omeprazole reduces the absorption of vitamin B12. This property must be taken into account only with prolonged treatment with Omez. Hypericum may reduce the effectiveness of therapy.
IPP with domperidone is a useful combination for heartburn and reflux. Concomitant use promotes better digestion.
Contraindications, side effects and overdose
Omez should not be taken with hypersensitivity to omeprazole or other components in capsules / tablets. Contraindication is the age of up to 1 year and the weight of the patient is less than 10 kg.
A side effect of omeprazole is a decrease in the level of magnesium in the body. At the same time, potassium and calcium concentrations may fall. With prolonged treatment with Omez, the risk of developing osteoporosis increases, fractures of the wrist and thigh are possible. ankle joint.
Reducing the acidity of the contents of the stomach creates the conditions for the penetration of bacteria into the digestive tract. The risk of salmonellosis, enteritis of an infectious origin increases. Occasionally, taking Omez is accompanied by diarrhea, flatulence, and abdominal pain. In most cases, these symptoms disappear with continued therapy.
Long-term treatment with omez is accompanied by a change in liver function. Rare side effects are hepatitis, liver failure, and encephalopathy. It is also possible a change in blood, the development of anemia, the appearance of a rash, alopecia.
There is no information about the negative effects of a single overdose. Without consequences, taking 160-400 mg of omeprazole per day is bypassed.This does not mean that Omez and complete analogues can be taken uncontrollably.
