Suprastinex is an innovative antihistamine that has a quick effect and effectively eliminates unpleasant allergy symptoms. But, before using this drug for therapeutic purposes, it is necessary to familiarize yourself with its instructions for use. After all, any disregard for the recommendations made may be harmful.

Release forms and composition (active substance)

The active ingredient of Suprastinex is levocetirizine dihydrochloride. In addition, the composition of the drug contains additional components, the presence of which ensures a uniform distribution of the active substance.

As auxiliary ingredients are:

  • sodium saccharinate;
  • titanium dioxide;
  • glycerol;
  • lactose monohydrate;
  • methyl parahydroxybenzoate;
  • glacial acetic acid;
  • silica;
  • macrogol;
  • magnesium stearate;
  • triacetin;
  • purified water;
  • monocrystalline cellulose;
  • propylene glycol.

The form of release of the medicine for allergies is tablets, drops.

In liquid form, Suprastinex differs in the active ingredient content of 5 mg per 1 ml of the product. Colorless drops are available in a dark bottle of 20 ml with a dispenser, which allows you to easily measure the required amount of funds. The medicine has an unobtrusive smell of vinegar.

Suprastinex tablets are odorless white in convex shape. They contain characteristic engraving E and 281 on the surface. The preparation in the form of tablets is packaged in a blister pack of 7 or 10 pcs.

Drops and tablets of the drug are additionally packed in cardboard boxes. In each of them there is an annotation to the tool with detailed recommendations for use, as well as with existing restrictions.

Pharmacological action, pharmacodynamics and pharmacokinetics

Suprastinex is part of a group of drugs that have an antihistamine, anti-allergic effect. The active component of the drug provokes a blockage of H1 - histamine receptors.

Suprastinex affects the initial - histamine-dependent and late - cell stage of the disease, and also reduces the spread of eosinophilic granulocytes, reduces vascular permeability, significantly reduces the release of inflammatory mediators. The drug stops the main allergic symptoms, and also prevents their onset, so experts prescribe a medicine not only to treat the disease, but also to prevent its development in the most likely periods of the year.

The main advantage of Suprastinex is that if the dosage is observed, it does not cause drowsiness or addiction. After ingestion on an empty stomach, the active component begins to act after 12 minutes, if during meals - within 1 hour. The therapeutic effect persists for 1 day.

When ingested, levocetirizine is rapidly absorbed into the intestine, after which it is transported to the liver, and from there into the bloodstream. The maximum concentration of the active substance is recorded 0.9 hours after administration. 90% of the drug binds to plasma proteins. In addition, a small amount (about 14%) is metabolized in the liver, resulting in the formation of an inactive metabolite. Excretion of the active component mostly occurs through the kidneys, and the remaining amount through the intestines after 4 days.

Why is the drug prescribed?

Suprastinex is recommended for allergies as a symptomatic treatment. The medicine is prescribed for adults, as well as for children with some age restrictions.

The main indications:

  • atopic conjunctivitis;
  • hay fever;
  • Quincke's edema;
  • allergic rhinitis;
  • urticaria, including idiopathic;
  • dermatosis, characterized by rashes and annoying itching.

Instructions for use Suprastineks for adults and children

The drug, regardless of the form of release, is taken orally before or during meals. The medicine has a prolonged effect, so you need to drink the daily rate for 1 time daily at the same time.

The duration of therapy is prescribed by the doctor, depending on the form of the allergy. In most cases, the course lasts from 1 to 6 weeks, but the clinical experience of using Suprastinex in an adult for six months has been recorded.

Since the excretion of levocetirizine occurs through the kidneys, for patients with impaired function of this organ, an adjustment to the daily norm is necessary. The amount of medicine, in this case, is indicated by the attending physician, based on data on the creatinine clearance value.

Suprastinex tablets

This form of medication is for adults and children over 6 years old. Suprastinex tablets should be taken without compromising the integrity of the surface. You can drink the drug with water.

Suprastinex has a prolonged effect, so the daily rate should be drunk in 1 dose. In this case, the maximum dosage is 5 mg for 24 hours.

Drop Formulation

Suprastinex drops have a more gentle effect on the body, so they are specially designed for children aged 2 to 6 years. The prescribed dosage of the medicine is poured into a teaspoon with a small amount of water. Drink the drug after dissolution.

Taking the medicine is prescribed twice a day, 5 drops each (which is equivalent to 1.25 mg) with a frequency of 10-12 hours. The maximum daily dosage is 2.5 mg.

During pregnancy and lactation

There is no reliable data on the action of Suprastinex confirming or refuting its negative effect on the fetus in different phases of development. Therefore, pregnant women are not allowed to use the medicine.

It is proved that levocetirizine passes into breast milk, therefore this drug is contraindicated for use during lactation. If you need to take Suprastinex, breastfeeding should be suspended.

Drug interaction

There is no clinical confirmation of the combination of Suprastinex with other drugs. Therefore, when prescribing a medicine, it is worth relying on data on the interaction of cetirizine racemate. Based on this, it was found that the combination of cimetidine, erythromycin, phenazone, pseudoephedrine, ketoconazole, diazepam, glipizide with this component does not give undesirable effects.

The simultaneous administration of cetirizine and theophylline showed that the clearance of the first component decreases by 16%, while the kinetics of the second does not change.

The simultaneous combination of ritonavir in an amount of 600 mg per day and cetirizine 10 mg over the same period of time showed that the exposure of the first is reduced by 10%, and the second is increased by 40%.

Compatibility Suprastinex with alcohol

Experts say that this drug for allergies is not able to potentiate the effect of alcohol on the body. But in people with hypersensitivity, when these components are combined, the risk of developing side effects increases.

In addition, the simultaneous administration of the drug with alcohol or other drugs that have a depressing effect on the central nervous system, can enhance the negative effect on the nervous system.

Contraindications, side effects and overdose

The instructions for Suprastinex indicate the main contraindications to the use of the drug. Therefore, before proceeding with its reception, you should carefully study this item.

It is not recommended to take this medicine for allergies with:

  • terminal form of renal failure;
  • hypersensitivity to lactose;
  • spinal cord injuries, tumors in the prostate gland and other pathological processes provoking urinary retention;
  • individual intolerance to any component of the drug;
  • pregnancy, breastfeeding;
  • less than 6 years of age (tablets) and less than 2 years of age (drops);
  • glucose malabsorption syndrome, galactose.

A relative limitation to admission is the chronic form of renal failure and the elderly patient who has reduced glomerular filtration function. In this case, a correction of the daily norm in a smaller direction is necessary. More accurate information about taking the medicine is indicated by the attending physician based on the tests performed.

In some cases, the drug causes drowsiness, so you should temporarily refuse to drive a car and perform work that requires an increased concentration of attention.

Suprastinex is a new generation of drugs, so its list of side effects is much less than other drugs with a similar effect.

But clinical studies have shown the likelihood of the following side effects in patients:

  • increased dryness in the oral cavity;
  • headache;
  • drowsiness;
  • vomiting
  • tremor;
  • anxiety;
  • increased irritability;
  • sleep disturbance;
  • depression;
  • increased appetite;
  • leg cramps;
  • thrombosis;
  • decreased visual acuity;
  • dizziness;
  • fainting;
  • tachycardia;
  • nausea;
  • shortness of breath
  • urinary retention;
  • muscle pain
  • skin rashes;
  • annoying itching.

Exceeding the daily intake of the drug leads to an overdose. In an adult patient, it is manifested by drowsiness, in children - by increased excitability, anxiety, which subsequently becomes drowsiness.

At the first sign of an overdose, you need to take activated charcoal, as well as effectively rinse the stomach. If these actions do not bring a positive result, you should call a doctor.

There is no special antidote to this drug, symptomatic therapy is prescribed. Hemodialysis in this case is ineffective.

Allergy drug analogues

You can replace the medication with the following drugs:

  • Zenaro
  • Levocetirizine-Teva;
  • Ceser;
  • Xizal;
  • Gletset;
  • Alerset L;
  • Zodak
  • Elcet.

Any of the proposed analogues of Suprastinex has its own characteristics of use and contraindications. Therefore, medications should be taken only after the appointment of a doctor, so that therapy does not lead to a complication of well-being.

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