Ibuprofen tablets are often prescribed to relieve pain and normalize body temperature. Their widespread use is explained by the therapeutic effect and effectiveness of the drug, which are fully studied, and also confirmed by relevant studies. This allowed Ibuprofen to be added to the WHO list of essential drugs.
Material Content:
- 1 The composition of the antipyretic
- 2 Pharmacological action, pharmacodynamics and pharmacokinetics
- 3 Why is ibuprofen prescribed
- 4 Instructions for use for adults and children
- 5 During pregnancy and lactation
- 6 Drug interaction
- 7 Ibuprofen Compatibility with Alcohol
- 8 Contraindications, side effects and overdose
- 9 Analogs
The composition of the antipyretic
The active component of the drug is a substance of the same name - ibuprofen. Its mass fraction in tablets may be 200 mg or 400 mg. In addition to ibuprofen, the composition of the drug includes auxiliary components that contribute to an even distribution of the main substance.
As additional elements are:
- magnesium stearate;
- carmuazine (E122);
- povidone;
- polysorbate 80;
- titanium dioxide (E171);
- potato starch;
- hypromellose;
- silicon dioxide colloidal anhydrous;
- polyethylene glycol 6000.
Pharmacological action, pharmacodynamics and pharmacokinetics
Ibuprofen is part of the group of NSAIDs (non-steroidal anti-inflammatory drugs) derivatives of propionic acid. The effectiveness of this drug is based on the suppression of prostaglandin synthesis in all body tissues and in the walls of blood vessels. The drug also prevents the formation of blood clots, as it prevents platelet aggregation (sticking).
Ibuprofen has established itself as an effective way to relieve pain, reduce heat and eliminate inflammation.
The active substance of the drug is able to be rapidly absorbed and evenly distributed throughout the body, providing a therapeutic effect. The component is excreted through the kidneys in full.
The maximum concentration level of ibuprofen in the blood is reached 45 minutes after taking the medicine on an empty stomach. When combined with food, this indicator is fixed after 1-2 hours. The half-life of the active component varies from 2 to 2.5 hours.
Why is ibuprofen prescribed
The drug is used as an independent tool, and as part of a comprehensive treatment, as an adjuvant for various pathologies.
Ibuprofen is able to provide a therapeutic effect in:
- rheumatoid arthritis, including Still's disease;
- pain against a background of sprain;
- osteoarthrosis;
- inflammation of the shell of the joints;
- ankylosing spondylitis;
- bursitis;
- tendonitis;
- tenosynovitis;
- pain in the lower back;
- painful menstruation;
- periodic or regular headache, as well as migraine;
- neuralgia;
- dysmenorrhea;
- postoperative and toothache.
As part of a comprehensive treatment, Ibuprofen is prescribed for adnexitis and proctitis. This medicine is also used to eliminate signs of fever with influenza and SARS.
Instructions for use for adults and children
Ibuprofen tablets are intended for oral administration. The minimum dose of the drug should be used for a short period: to stop the pain - 5 days, and to reduce fever - 3 days. If during this time the symptoms do not begin to weaken, then the medication should be stopped and consult a specialist.
It is permissible to prescribe Ibuprofen to adults and children over 6 years old if their weight exceeds 20 kg. With reduced body weight, it is forbidden to use this medicine, even after reaching the specified age.
The dosage of Ibuprofen for children and adults, according to the instructions for use, is calculated depending on the weight of the patient in a proportion of 20-30 mg per 1 kg per day. Exceeding the norm is prohibited, so as not to provoke the development of side effects. You can take the medicine regardless of the meal, and drink it with water.
Ibuprofen tablets 200 mg
The norm of the drug of this form of release for adults and children weighing over 30 kg is 1-2 tablets every 6 hours. But with a maximum daily dosage of not more than 1200 mg of the drug, which is 6 tablets of Ibuprofen 200 mg.
For children whose weight is from 20 to 30 kg (6-11 years), it is permissible to take 1 tablet (200 mg) once every 6 hours. But at the same time, the maximum amount of the drug per day should not exceed 600 mg (3 tablets).
400 mg ibuprofen tablets
This form of release of the drug is intended solely for adult patients. Taking the medicine should be carried out regardless of food 1 time in 6 hours, drinking 1 tablet.
In aggregate, the maximum daily intake is 1200 mg (3 tablets of 400 mg each).
No adjustment of the ibuprofen intake norm is required for people of the older age group, as well as for patients suffering from mild, moderate degree renal and hepatic function.
During pregnancy and lactation
It is permissible to prescribe Ibuprofen to pregnant women in the early stages of gestation, when the potential benefit exceeds the potential threat. According to experts, the drug is not able to disrupt the normal development of the baby in the womb during the 1st and 2nd trimester.
But at the same time, gynecologists try to avoid the use of the drug during pregnancy, since it refers to NSAIDs, which increase the likelihood of miscarriage by 2.4 times.
In the case of breastfeeding, Ibuprofen is a rare exception, since the active component of the drug practically does not enter the milk.Therefore, it is completely safe for the baby.
But if necessary, you can completely prevent even a minimal ingestion of the drug into the child's body. For this, it is enough to take into account that its highest concentration in the blood is observed for 30-120 minutes after administration. Therefore, during this period, it is necessary to avoid breastfeeding.
Drug interaction
The combination of ibuprofen with other drugs should be prescribed by a doctor. Any personal initiative of the patient can not only lead to the absence of the effect of therapy, but can also provoke the development of side effects.
Features of the interaction of ibuprofen with other medicines:
| Name | Combination result |
|---|---|
| Acetylsalicylic acid | Ibuprofen suppresses the anti-aggregation and anti-inflammatory effects of aspirin and increases the likelihood of coronary insufficiency |
| Other NSAIDs including selective cyclooxygenase-2 inhibitors | The likelihood of side effects increases several times |
| Corticosteroids | The possibility of bleeding and ulcers in the digestive tract |
| Diuretics and antihypertensive drugs | Ibuprofen reduces the effectiveness of these drugs, as well as impaired renal function. |
| Tacrolimus | Possible nephrotoxicity |
| Anticoagulants (Warfarin) | Their effect is enhanced |
| Thrombolytic drugs (Alteplase, Urokinase, Streptokinase) | The probability of internal bleeding increases |
| Cardiac Glycosides | The functioning of the heart muscle is impaired, glomerular filtration of the kidneys decreases, the concentration of glycosides in the blood increases |
| Cefamandol, cefotetan, cefoperazone | The occurrence of hypoprothrombinemia is increasing |
| Tubular secretion blockers | The content of ibuprofen in the blood rises and its excretion is accelerated |
| Mifepristone | Ibuprofen can be taken after 8-12 days after taking mifepristone, since NSAIDs inhibit its effectiveness |
| Quinolone antibiotics | Increased likelihood of seizures of limbs |
| Lithium-containing medicines | The concentration of lithium in the body increases |
Relieving pain is enhanced by combining Ibuprofen with caffeine to a reasonable extent.
Ibuprofen Compatibility with Alcohol
According to the instructions, taking the medicine in combination with alcohol is not recommended. This is due to the oxidation of xenobiotics, which are present in both components.
As part of Ibuprofen, they serve as catalysts, confirming the positive reaction of the body to the therapeutic effect of the drug. That is, at their minimum concentration, the metabolic process takes place at a slower pace, which makes it possible for them to act in a timely manner. Therefore, the patient quickly feels the analgesic effect of the drug.
When combining the drug with alcohol, an increased content of xenobiotics is observed. This leads to an acceleration of their metabolism, since the body in this way tries to protect itself from toxins. As a result, the analgesic effect of the drug will be slower or may not occur. A more deplorable result of the combination of Ibuprofen with alcohol can be damage to hepatocytes, which threatens with serious complications.
Contraindications, side effects and overdose
Like any other drug, Ibuprofen has a number of intake restrictions that you need to pay attention to before starting therapy.
The main contraindications:
- intolerance to any component that is part of the drug;
- 3 trimester of pregnancy;
- erosive and ulcerative pathologies of the digestive tract;
- bronchial asthma;
- renal, cardiac, and liver failure;
- age less than 6 years;
- hypertension
- bleeding disorder;
- tendency to bleeding;
- pathology of the optic nerve;
- alcoholism,
- severe somatic diseases;
- blood pathology of unknown etiology.
An overdose of the drug can occur only if you ignore acceptable standards and do not meet the waiting time between doses.For an adult, a critical indicator is 80-100 mg of ibuprofen per 1 kg of weight, and for a child - 40 mg. In this case, symptoms of intoxication appear 4 hours after taking the drug. The duration of the removal of the component is 1.5-3 hours.
Characteristic side effects:
- drowsiness;
- nausea;
- discomfort in the epigastric region;
- dizziness;
- noise in ears;
- diarrhea;
- confusion of consciousness;
- hearing impairment;
- hallucination;
- unjustified anxiety;
- leg cramps;
- itching
- dyspnea;
- hypotension;
- hives;
- vomiting
- laryngeal edema.
There is no special antidote for eliminating signs of overdose. Therefore, treatment is carried out commensurate with the severity of the patient's condition. With minimal manifestations of symptoms, it is recommended to drink more water to neutralize the negative effect of the drug. In case of a complicated situation, activated charcoal or gastric lavage is used if no more than 1 hour has passed after taking the drug. In critical condition of the patient should call a doctor.
Analogs
If necessary, Ibuprofen can be replaced with other drugs with a similar therapeutic effect.
List of analogues:
- ArthroCam;
- Next;
- Nurofen;
- Ibuprom;
- It is long;
- Ibufen
- Suprafen;
- Ibunorm;
- Novigan.
It should be understood that Ibuprofen and its analogues only help to eliminate unpleasant symptoms, but they can not cure the disease. Therefore, to restore health, you should undergo a course of necessary therapy prescribed by your doctor.
