Muscle spasm is almost always accompanied by a pain syndrome that fetters movement. Effectively cope with the problem arose under the power of tablets "Midokalm". The drug refers to muscle relaxants of a central action, the result of which is a decrease in muscle tension, relieve spasm and relieve pain.

Composition, release form and packaging

Midokalm is available in two dosage forms: injection and tablets. The latter are more popular, because they are more convenient to use. The main active ingredient of the muscle relaxant is tolperisone hydrochloride. Two dosages of the active ingredient are available: 50 mg and 150 mg. The composition of the tablets also includes talc, corn starch, cellulose, etc.

Doses are placed in a blister. In each - 10 pieces. In a cardboard box 3 blisters. The average price is 250 rubles. The original drug is produced by the pharmaceutical company Gideon Richter (Hungary). On sale are tablets of Russian manufacture, which are manufactured under license.

Pharmacological properties and pharmacokinetics

The mechanism of action of the drug is not fully understood. The main active component has the ability to slow down the conductivity of nerve impulses in motor neurons and afferent fibers.As a result of taking the medication, specific reflexes are blocked, peripheral blood flow increases, and muscle tension is relieved. Tolperisone hydrochloride has a local anesthetic, adrenergic blocking, antispasmodic effect.

The active substance of the drug is absorbed from the digestive tract. The maximum concentration of tolperisone in the blood is reached after 30 - 60 minutes after administration. Cleavage occurs in the liver and kidneys. About 99% of the metabolites are administered in the urine.

Why is the drug prescribed?

The scope of muscle relaxant is quite wide. The action of the drug is aimed at reducing muscle tone, respectively, and the indications are associated with conditions associated with muscle spasm.

Muscle tissue overstrain can occur for one of two reasons: malfunctioning of the central nervous system or improper functioning of the musculoskeletal system.

Medokalm tablets are prescribed for such diseases:

  • multiple sclerosis;
  • encephalopathy of various etiologies;
  • Little's disease;
  • myelopathy
  • encephalitis;
  • osteochondrosis;
  • stroke;
  • diabetic angiopathy;
  • diffuse scleroderma;
  • hemorrhoids;
  • prostatitis, etc.

Effective "Midokalm" for injuries and sprains of muscles. The active component of the pill relieves muscle spasms caused by impaired functioning of the central nervous system or brain. The drug is recommended for patients during the rehabilitation period after orthopedic operations and complex injuries.

Instructions for use of tablets Midokalm 50, 150 mg

Take "Midokalm" must be strictly prescribed. You can not buy medicine on your own at a pharmacy and begin a course of treatment without consulting a specialist. The dosage schedule is described in detail in the instructions for use. If necessary, it is adjusted depending on the diagnosis, the specific course of the disease, the patient’s health status.

Standard dosages:

  • 1 - 3 tab. 50 mg three times a day;
  • 1 tab. 150 mg three times a day.

The daily dose of the active substance should not exceed 500 mg.

If the drug is used to treat pediatric patients, the amount of active ingredient is calculated individually.

To determine the dose using the formula:

  • up to 6 years - 5 mg / kg;
  • 7-14 years old - 2-4 mg / kg.

The resulting value is divided by 3 and receive a single dose. If the child still cannot swallow the tablets, they are ground into powder, which is diluted with a small amount of clean water.

During pregnancy and lactation

The components of the drug "Midokalm" do not have a negative effect on the condition of the fetus and do not affect the course of pregnancy, therefore, the use of this drug is not contraindicated for women during the period of gestation. However, you can start the course only after consulting with a specialist.

With extreme caution, muscle relaxant should be used in the first trimester.

In the last months of pregnancy, pills can be taken to prevent premature birth if the uterus is in good shape.

Midokalm nursing mothers are not prescribed.

Can I drink alcohol while taking the drug

The simultaneous use of alcohol-containing drinks and tablets "Midokalm" does not adversely affect the patient's condition.

Drug interaction

The active substance of the drug has the ability to increase the concentration of the active components of such drugs:

  • "Perphenazine";
  • "Metoprolol";
  • Desipramine;
  • "Thioridazone" and others.

"Midokalm" has a slight sedative effect, so the dosage must be reduced in the case of the use of other muscle relaxants. The drug enhances the action of non-steroidal anti-inflammatory drugs.

Special instructions for admission

Midokalm tablets are recommended to be taken after meals. Fasting is not worth it. Food increases the bioavailability of the active ingredient.

The use of muscle relaxant does not affect the ability to drive vehicles or other mechanisms.

If, after taking the pill, the patient's condition worsens, you should consult your doctor.

Contraindications, side effects and overdose

The list of contraindications is small. Do not use the medicine for allergy-prone people, as well as for those patients who have found hypersensitivity to the components of the drug. Do not prescribe "Midokalm" in tablets to newborn babies who have not yet turned 1 year old. Myasthenia gravis is also a contraindication to therapy under discussion.

The likelihood of adverse reactions due to the use of a medication is low, but there is.

Most often, patients encounter such unpleasant manifestations:

  • headache;
  • change in blood pressure;
  • vomiting and nausea;
  • skin rashes;
  • heart palpitations;
  • edema, localized mainly on the face and hands;
  • noise in ears;
  • decreased performance, etc.

As a rule, these effects disappear after discontinuation of the drug. In rare cases, after taking tablets, patients are disturbed by insomnia, nosebleeds, anemia, angina pectoris, bradycardia, etc. Anaphylactic shock is not excluded.

There is no reliable information about overdose cases. Studies have been conducted involving animals.

In experimental individuals, due to the use of the drug at a dose higher than recommended, the following disorders were observed:

  • tonic clinical cramps;
  • ataxia;
  • paralysis of the respiratory center.

If the patient accidentally or intentionally took a high dose, you should do a gastric lavage, drink a drug with an absorbing effect (activated charcoal, White Sorbent, etc.) and, if necessary, go to a medical institution or call an ambulance.

There is no specific antidote for muscle relaxant. Symptomatic therapy is carried out aimed at stabilizing the patient's condition.

Analogues of tablets Midokalm

The drug "Midokalm" has established itself as an effective, safe, inexpensive muscle relaxant. It is popular both among patients and among professionals. The pharmaceutical market offers a wide range of drugs that are characterized by the same composition and / or have a similar pharmacological effect. Below is a list of the most common substitutes for Midokalm.

  • Miolgin. The composition of this medication also includes paracetamol, so the drug has not only an antispasmodic and analgesic effect, but also lowers the temperature. Miolgin is not prescribed for expectant and lactating mothers, as well as for patients who are under the age of 18.
  • Sirdalud. This drug is highly effective, therefore it is advisable to use it even with severe muscle spasms. Take the drug 1 time per day. Side effects occur infrequently. After taking the medication, patients sometimes complain of weakness and drowsiness.
  • "Tolperizon." A popular analogue of Midokalm in tablets. An absolute synonym, which includes the same active substance. The drug is also available in injections. Its main advantage is low cost. The drug is prescribed for cramping and overstrain of muscle tissue, as well as in the rehabilitation period after surgical interventions.
  • "Baclofen." A potent drug that is rarely prescribed due to the high probability of adverse reactions, including tachycardia, anemia, hyperthermia.

If you notice that the effect of the use of Midokalm tablets is weak or very strong, do not resort to dose adjustment, cancellation or replacement of the drug yourself.

This can have negative consequences for your health. Report your complaints to your doctor. He will study the clinical picture of the disease, based on the examination and analysis results, he will select the most suitable drug and its optimal dosage, which is relevant specifically in your case.

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