According to the instructions for use, Ursosan refers to drugs that have a hepatoprotective effect. The medication protects hepatocytes and liver cells from toxins, preventing their death, improves bile outflow, and helps dissolve and remove stones.

Release form, composition and packaging

Ursosan is published by a Czech company. The drug is presented:

  • white capsules with a homogeneous powdery component. The drug is packaged in cardboard boxes of 50 pcs. in each;
  • enteric-coated tablets, enteric coated. One package contains 10 tablets.

A substance that has an active effect on the body is ursodeoxycholic acid. It contains 250 mg in one capsule form.

In addition to the active ingredient, the drug consists of the following ingredients:

  • corn starch;
  • gelatin;
  • silica;
  • magnesium stearate.

Ursosan tablets consist of 500 mg of the active ingredient and the following substances that do not have a therapeutic effect on the body:

  • corn starch;
  • silica;
  • macrogol;
  • magnesium stearate;
  • sodium carboxymethyl starch;
  • Opadra white.

Pharmacological action, pharmacodynamics and pharmacokinetics

Ursosan has the following pharmacological effects exerted by ursodeoxycholic acid:

  • reduces the viscosity of bile, which occurs as a result of the breakdown of minerals;
  • accompanies bile to the area of ​​the duodenum;
  • reduces the concentration of bile due to a decrease in its synthesis;
  • improves the activity of the pancreas, stomach;
  • does not allow the formation of fibrosis, cirrhosis;
  • increases immunity as a result of the prevention of pathologies of liver cells.

Due to its pharmacological properties, Ursosan has a powerful antioxidant effect on hepatocytes. After entering the body, after 1.5 hours, ursodeoxycholic acid is determined in the maximum amount in the circulatory system. The cleavage process occurs in the liver cells. Most of the medication is excreted through bile. A small volume penetrates the intestines.

What is Ursosan prescribed for?

It is necessary to use Ursosan strictly with the appointment of a specialist. Doctors often prescribe a medication to treat the following conditions:

  • uncomplicated cholelithiasis;
  • acute hepatitis;
  • hepatocytes damaged by toxins;
  • dyskinesia;
  • cystosis of the liver;
  • steatohepatitis;
  • artesia;
  • cholangitis;
  • reflux conditions.

To prevent the further formation of stones against the background of the use of oral contraceptives, treatment with cytostatics, this drug is used for prevention. Often Ursosan is used as part of complex therapy of oncology. In pediatrics, the drug is prescribed for the diagnosis of newborn jaundice, if after a month there has not been an improvement in the results of laboratory tests.

Instructions for use and dosage of tablets

To get great benefits from treatment, Ursosan is washed down with enough water. The dosage of the drug varies from the age of the patient, his weight, type of pathology, its degree of development.

To alleviate the condition with esophagitis reflux, the drug is drunk for 14 days, 1 tablet each. before bedtime. If the condition does not improve, then prolongation of therapy is possible up to a year. To prevent the formation of stones in the gallbladder, Ursosan is prescribed twice in 250 mg for at least 6 months.

To alleviate the condition of the patient with cirrhosis, usually take from 2 to 5 tablets. per day. The treatment is quite long, sometimes lasting several years.

To alleviate the condition of liver damage from toxins caused by the negative influence of drugs, alcohol, the maximum dose is calculated, where 15 mg of the drug per 1 kg of weight. The resulting dosage is taken 2 times. Therapy lasts up to 6 months.

To remove cholesterol stones from the biliary tract, Ursosan is taken for a long time. Sometimes the course lasts several years. Calculation of dosage is based on the weight of the patient. In this case, 1 mg of the drug accounts for 10 mg of the drug.

 

In secondary disorders in the form of diffuse disorders, the maximum dosage is divided into 3 doses. To alleviate the condition with cholelithiasis, the recommended amount of drink once, at night. Therapy continues until the gallstones dissolve and clear. Further, in order to prevent their formation, Ursosan is prescribed to take up to 3 months.

For the treatment of cholangitis, a calculation is required. For 1 kg of patient weight, 12 mg of the drug. The resulting dose is divided into two doses. Non-alcoholic steatohepatitis can be eliminated by taking medication at the rate of 15 mg per 1 kg of weight twice a day.

Note. To treat children, you should calculate the dose of Ursosan. For 1 kg of a child’s weight, 10 mg of the drug is necessary.

During pregnancy and breastfeeding

Before taking Ursosan while bearing a child, a woman should obtain a doctor’s permission. This is important for assessing the expected benefits for the mother and the perceived risk for the unborn child. Ursosan is usually recommended during pregnancy to drink 1 capsule in the evening for a month.

Nursing women, after the appointment of a doctor, can also be treated with Ursosan.

Drug interaction

Ursosan is taken with caution with certain groups of drugs:

  • with antacids, the concentration of the active component decreases. If necessary, simultaneous treatment with such drugs should observe a two-hour interval between doses;
  • with oral contraceptives, the risk of bile duct stones increases;
  • with cyclosporine, the absorption of the immunosuppressant increases;
  • with ciprofloxacin, the absorption of the antibacterial agent decreases.

Contraindications, side effects and overdose

It is not recommended to take Ursosan if the patient suffers from the following conditions:

  • intolerance to the active substance;
  • impaired functioning of the gallbladder;
  • hepatitis A;
  • pancreatitis
  • gallbladder infection;
  • cholangitis;
  • cholecystitis;
  • fistulas in the digestive tract;
  • severe kidney pathologies;
  • calcined stones.

According to indications, under the strict supervision of a doctor, Ursosan is taken by pregnant and lactating women.

Ursosan has many side effects, manifested by negative reactions of the body in the form of:

  • vomiting
  • dermatitis;
  • constipation
  • itching
  • urticaria;
  • nausea
  • pain in the back;
  • increased amounts of AST enzymes;
  • damage to hair follicles;
  • enrichment of gallstones with calcium.

In case of side effects, an adjustment of the use of Ursosan is necessary. To do this, reduce its dose.

Medicine does not have data on overdose facts.

Analogs

If necessary, it is possible to replace Ursosan with an analogue of the active component, which has a similar effect on the body.

To do this, appoint a reception:

  • Ursomax;
  • Ursolac
  • Essential;
  • Ursoliva;
  • Holudexan;
  • Ursolysin;
  • Greenterol;
  • Ursokhol;
  • Ursonosta;
  • Ursofalka.

All analogues of Ursosan have individual characteristics. On this basis, it is forbidden to independently replace the pharmaceuticals. Consultation of the attending physician is required.

Comparative characteristics with Ursofalk and Greenterol

Before starting treatment, patients often ask themselves what to choose, Greenterol or Ursosan. Both medicines are related to the group of hepatoprotectors. They have a choleretic effect. They contain the same component that has an active effect on the body - ursodeoxycholic acid. Medicines are created in capsule form. One capsule contains 250 mg of the active substance.

Medicine has not conducted a comparative study of these drugs. But there is evidence that 60% of patients taking Greenterol were cured of the initial stage of formation of liver stones by taking the medicine for 2 months. Collecting analyzes in patients with the initial stage of gallstone disease, it was found that 85% got rid of microliths, taking Ursosan for 3 months.

Important! The appointment of an analogue of Ursosan should only be done by a doctor after assessing the condition of the patient, the type of microliths, and the degree of the disease. Since each drug has individual side effects, contraindications.

When it is necessary to evaluate which is better, Ursosan or Ursofalk, then you should get patient feedback, the results of clinical data. Patients typically experience better tolerance of Ursofalk. It has fewer side effects. Doctors note that under the influence of Ursofalk, gallstones dissolve more quickly and the functioning of the liver normalizes.

But we must not forget about the individual characteristics of the body. Not all people tolerate Ursofalk equally well. There are patients for whom Ursosan will be preferable. You can choose the optimal drug only after passing a course of treatment with one, and then a second medication. And then compare the results in a laboratory way, and guided by their own feelings.

Ursosan is a single drug whose active substance has an antioxidant effect, helps to eliminate stones.The drug is prescribed for both the adult and children's population.

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